HS-LS1-7

ScienceGrades 9–12From Molecules to Organisms: Structures and Processes

The standard

Use a model to illustrate that cellular respiration is a chemical process whereby the bonds of food molecules and oxygen molecules are broken and the bonds in new compounds are formed resulting in a net transfer of energy.

Next Generation Science Standards

What this standard means

Students need to use a model to show what goes into cellular respiration, what comes out, and how energy is transferred. They should connect glucose and oxygen to carbon dioxide, water, and usable energy without memorizing glycolysis, Krebs cycle, or electron transport details.

Mastery looks like a labeled diagram, particle model, or equation model that shows atoms rearranging and energy moving from chemical bonds to the cell. Students often think energy is “made,” that oxygen becomes energy, or that respiration means breathing only.

Ways to teach it

  • Hands-on: Give students molecule cards for glucose and oxygen, then have them rearrange atoms into carbon dioxide and water with energy tokens released.
  • Prompt: Explain why cellular respiration is not just breathing, using the words glucose, oxygen, carbon dioxide, water, and energy.
  • Quick assessment: Show an unlabeled respiration model and ask students to label inputs, outputs, and where energy transfer is shown.
  • Real-world connection: Have students compare a resting athlete and sprinting athlete, then explain why muscle cells need more glucose and oxygen.

Plan a lesson for HS-LS1-7

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Related standards

  • MS-LS1-7

    Develop a model to describe how food is rearranged through chemical reactions forming new molecules that support growth and/or release energy as this matter mov...

  • HS-LS2-5

    Develop a model to illustrate the role of photosynthesis and cellular respiration in the cycling of carbon among the biosphere, atmosphere, hydrosphere, and geo...

  • HS-PS1-4

    Develop a model to illustrate that the release or absorption of energy from a chemical reaction system depends upon the changes in total bond energy.

  • HS-LS1-5

    Use a model to illustrate how photosynthesis transforms light energy into stored chemical energy.

Standard text verified against nextgenscience.org on July 10, 2026.

Page updated July 10, 2026.

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